Structure and Semisynthesis of Platensimide A, Produced by Streptomyces platensis
- 8 April 2008
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 10 (9), 1699-1702
- https://doi.org/10.1021/ol800251v
Abstract
Platensimycin and platencin are novel natural product antibiotics that inhibit bacterial growth by inhibiting condensing enzymes FabF and FabF/FabH of fatty acid biosynthesis pathways, respectively. Continued search for the natural congeners of these compounds led to the isolation of platensic acid, the free C-17 tetracyclic enoic acid, and platensimide A, a 2,4-diaminobutyric acid amide derivative. Isolation, structure, semisynthesis, and activity of these compounds are described.Keywords
This publication has 8 references indexed in Scilit:
- Biosynthetic Studies of PlatensimycinJournal of the American Chemical Society, 2007
- Chemistry of platensimycinTetrahedron Letters, 2007
- Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad‐Spectrum Antibiotic ActivityAngewandte Chemie-International Edition, 2007
- Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic propertiesProceedings of the National Academy of Sciences, 2007
- Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity StrategyJournal of the American Chemical Society, 2006
- Platensimycin is a selective FabF inhibitor with potent antibiotic propertiesNature, 2006
- Discovery of FabH/FabF Inhibitors from Natural ProductsAntimicrobial Agents and Chemotherapy, 2006
- Determination of Selectivity and Efficacy of Fatty Acid Synthesis InhibitorsJournal of Biological Chemistry, 2005