Role of Basal Ganglia in Sleep–Wake Regulation: Neural Circuitry and Clinical Significance
Open Access
- 1 January 2010
- journal article
- Published by Frontiers Media SA in Frontiers in Neuroanatomy
- Vol. 4, 145
- https://doi.org/10.3389/fnana.2010.00145
Abstract
Researchers over the last decade have made substantial progress toward understanding the roles of dopamine and the basal ganglia (BG) in the control of sleep–wake behavior. In this review, we outline recent advancements regarding dopaminergic modulation of sleep through the BG and extra-BG sites. Our main hypothesis is that dopamine promotes sleep by its action on the D2 receptors in the BG and promotes wakefulness by its action on D1 and D2 receptors in the extra-BG sites. This hypothesis implicates dopamine depletion in the BG (such as in Parkinson’s disease) in causing frequent nighttime arousal and overall insomnia. Furthermore, the arousal effects of psychostimulants (methamphetamine, cocaine, and modafinil) may be linked to the ventral periaquductal gray (vPAG) dopaminergic circuitry targeting the extra-BG sleep–wake network.Keywords
This publication has 78 references indexed in Scilit:
- D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortexProceedings of the National Academy of Sciences of the United States of America, 2010
- Evolution of Neurological, Neuropsychological and Sleep-Wake Disturbances After Paramedian Thalamic StrokeStroke, 2008
- Pharmacological Modulation of Dopaminergic Brain Activity and Its Reflection in Spectral Frequencies of the Rat ElectropharmacogramNeuropsychobiology, 2008
- Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wakeJournal of Neuroscience, 2007
- Insomnia following hypocretin2-saporin lesions of the substantia nigraNeuroscience, 2006
- Insomnia in Parkinson's disease: frequency and progression over timeJournal of Neurology, Neurosurgery & Psychiatry, 2006
- Sleep-related problems of Parkinson’s diseaseAge and Ageing, 2006
- Sleep Disorders in Patients with Parkinson??s DiseaseCNS Drugs, 2001
- Nocturnal sleep structure and temperature slope in MPTP treated monkeysJournal of Neural Transmission, 1999
- Amphetamine Induces Hypermotility in MPTP-Lesioned MicePharmacology Biochemistry and Behavior, 1997