Myocardial knockdown of mRNA‐stabilizing protein HuR attenuates post‐MI inflammatory response and left ventricular dysfunction in IL‐10‐null mice
Open Access
- 12 February 2010
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 24 (7), 2484-2494
- https://doi.org/10.1096/fj.09-149815
Abstract
Prolonged inflammatory response is as sociated with left ventricular (LV) dysfunction and adverse remodeling following myocardial infarction (MI). IL-10 inhibits inflammation by suppressing HuR-media...Keywords
Funding Information
- Institut National de la Santé et de la Recherche Médicale (AA014575, HL091983)
This publication has 49 references indexed in Scilit:
- HuR is exported to the cytoplasm in oral cancer cells in a different manner from that of normal cellsBritish Journal of Cancer, 2009
- Divergent Tumor Necrosis Factor Receptor–Related Remodeling Responses in Heart FailureCirculation, 2009
- IL-10 Inhibits Inflammation and Attenuates Left Ventricular Remodeling After Myocardial Infarction via Activation of STAT3 and Suppression of HuRCirculation Research, 2009
- miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levelsProceedings of the National Academy of Sciences of the United States of America, 2008
- Acute myocardial infarction induced increases in plasma tumor necrosis factor-α and interleukin-10 are associated with the activation of poly(ADP-ribose) polymerase of circulating mononuclear cellInternational Journal of Cardiology, 2008
- Negative inotropic effects of tumour necrosis factor‐α and interleukin‐1β are ameliorated by alfentanil in rat ventricular myocytesBritish Journal of Pharmacology, 2007
- Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGFProceedings of the National Academy of Sciences of the United States of America, 2006
- p38 Mitogen Activated Protein Kinase Mediates Both Death Signaling and Functional Depression in the HeartThe Annals of Thoracic Surgery, 2005
- NF-κB-Mediated MyoD Decay during Muscle Wasting Requires Nitric Oxide Synthase mRNA Stabilization, HuR Protein, and Nitric Oxide ReleaseMolecular and Cellular Biology, 2005
- ATP Potentiates Interleukin-1β-induced MMP-9 Expression in Mesangial Cells via Recruitment of the ELAV Protein HuRJournal of Biological Chemistry, 2003