The Human Muscle Proteome in Aging
- 3 May 2006
- journal article
- Published by American Chemical Society (ACS) in Journal of Proteome Research
- Vol. 5 (6), 1344-1353
- https://doi.org/10.1021/pr050414x
Abstract
The aim of the present study was to assess age-dependent changes of proteins in the vastus lateralis muscle of physically active elderly and young subjects by a combination of two-dimensional difference gel electrophoresis, SDS-PAGE and ESI-MS/MS. The differences observed in the elderly group included down-regulation of regulatory myosin light chains, particularly the phosphorylated isoforms, a higher proportion of myosin heavy chain isoforms 1 and 2A, and enhanced oxidative and reduced glycolytic capacity.This publication has 31 references indexed in Scilit:
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