Aphthous Ulceration: The Antinuclear Factor

Abstract
The incidence of the antinuclear factor in serum of patients with Mikulicz's recurrent oral aphthae (MROA) was compared with that in control serum. The absence of any difference between the two groups suggests that MROA is not an autoimmune disease arising from a central immunologic fault, but could be a local immune response against an antigenically altered mucosa.