Alprazolam and Exposure for Panic Disorder with Agoraphobia
- 1 May 1994
- journal article
- clinical trial
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 164 (5), 652-659
- https://doi.org/10.1192/bjp.164.5.652
Abstract
Patients with panic disorder plus agoraphobia had 8 weeks of drug treatment (alprazolam or placebo) plus psychological treatment (exposure or relaxation). At the end of treatment at week 8, 40 patients who had become much/very much improved rated how much their gains were attributable to medication or to their own efforts. During the tapering-off to week 16, and treatment-free follow-up to week 43, patients who at week 8 had attributed their gains to medication and felt less confident in coping without tablets had more severe withdrawal symptoms and greater loss of gains than did patients who at week 8 had attributed their gains to their own efforts during treatment. Baseline illness severity, greater age, higher expectations from drug treatment, and more side-effects of drugs during treatment all predicted more external attributions (i.e. to the effect of drugs) but did not independently predict relapse. Patients on alprazolam compared with placebo had more drug attributions. Though drug attributions predicted relapse in both alprazolam and placebo groups, predictions were stronger in the alprazolam group.Keywords
This publication has 29 references indexed in Scilit:
- Role of exposure homework in phobia reduction: A controlled studyBehavior Therapy, 1992
- Drug Treatment of Panic Disorder: Comparative Efficacy of Alprazolam, Imipramine, and PlaceboThe British Journal of Psychiatry, 1992
- Avoidance behaviour: A predictor of the efficacy of pharmacotherapy in panic disorder?Archiv Fur Psychiatrie Und Nervenkrankheiten, 1991
- Alprazolam in Panic Disorder and Agoraphobia: Results From a Multicenter TrialArchives of General Psychiatry, 1988
- Clomipramine, Self-exposure and Therapist-aided Exposure for Obsessive–Compulsive RitualsThe British Journal of Psychiatry, 1988
- Brief standard self-rating for phobic patientsBehaviour Research and Therapy, 1979
- The effect of treatment attributions on the maintenance of weight reduction: A replication and extensionCognitive Therapy and Research, 1979
- Severe Agoraphobia: A Controlled Prospective Trial of Behaviour TherapyThe British Journal of Psychiatry, 1966
- A RATING SCALE FOR DEPRESSIONJournal of Neurology, Neurosurgery & Psychiatry, 1960
- THE ASSESSMENT OF ANXIETY STATES BY RATINGPsychology and Psychotherapy: Theory, Research and Practice, 1959