Incorporation of Preprocedural PET into CT-Guided Radiofrequency Ablation of Hepatic Metastases: a Nonrigid Image Registration Validation Study
Open Access
- 27 May 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Digital Imaging
- Vol. 23 (6), 780-792
- https://doi.org/10.1007/s10278-009-9204-x
Abstract
This study evaluates the accuracy of augmenting initial intraprocedural computed tomography (CT) during radiofrequency ablation (RFA) of hepatic metastases with preprocedural positron emission tomography (PET) through a hardware-accelerated implementation of an automatic nonrigid PET-CT registration algorithm. The feasibility of augmenting intraprocedural CT with preprocedural PET to improve localization of CT-invisible but PET-positive tumors with images from actual RFA was explored. Preprocedural PET and intraprocedural CT images from 18 cases of hepatic RFA were included. All PET images in the study originated from a hybrid PET/CT scanner, and PET-CT registration was performed in two ways: (1) direct registration of preprocedural PET with intraprocedural CT and (2) indirect registration of preprocedural CT (i.e., the CT of hybrid PET/CT scan) with intraprocedural CT. A hardware-accelerated registration took approximately 2 min. Calculated registration errors were 7.0 and 8.4 mm for the direct and indirect methods, respectively. Overall, the direct registration was found to be statistically not distinct from that performed by a group of clinical experts. The accuracy, execution speed, and compactness of our implementation of nonrigid image registration suggest that existing PET can be overlaid on intraprocedural CT, promising a novel, technically feasible, and clinically viable approach for PET augmentation of CT guidance of RFA.Keywords
This publication has 46 references indexed in Scilit:
- Technologies for Guidance of Radiofrequency Ablation in the Multimodality Interventional Suite of the FutureJournal of Vascular and Interventional Radiology, 2007
- Automatic elastic image registration by interpolation of 3D rotations and translations from discrete rigid-body transformationsMedical Image Analysis, 2006
- RFA for Liver Tumors: Does It Really Work?The Oncologist, 2006
- Tissue deformation and shape models in image-guided interventions: a discussion paperMedical Image Analysis, 2005
- Mutual-information-based registration of medical images: a surveyIEEE Transactions on Medical Imaging, 2003
- PET-CT image registration in the chest using free-form deformationsIEEE Transactions on Medical Imaging, 2003
- An overlap invariant entropy measure of 3D medical image alignmentPattern Recognition, 1999
- Analysis of prognostic risk factors in hepatic resection for metastatic colorectal carcinoma with special reference to the surgical marginBritish Journal of Surgery, 1997
- Multimodality image registration by maximization of mutual informationIEEE Transactions on Medical Imaging, 1997
- Hepatic metastases: CT versus MR imaging at 1.5TAbdominal Radiology, 1991