The colorectal cancer epidemic: challenges and opportunities for primary, secondary and tertiary prevention
Top Cited Papers
Open Access
- 4 October 2018
- journal article
- review article
- Published by Springer Science and Business Media LLC in British Journal of Cancer
- Vol. 119 (7), 785-792
- https://doi.org/10.1038/s41416-018-0264-x
Abstract
Colorectal cancer (CRC) is both one of the most common and one of the most preventable cancers globally, with powerful but strongly missed potential for primary, secondary and tertiary prevention. CRC incidence has traditionally been the highest in affluent Western countries, but it is now increasing rapidly with economic development in many other parts of the world. CRC shares several main risk factors, such as smoking, excessive alcohol consumption, physical inactivity and being overweight, with other common diseases; therefore, primary prevention efforts to reduce these risk factors are expected to have multiple beneficial effects that extend beyond CRC prevention, and should have high public health impact. A sizeable reduction in the incidence and mortality of CRC can also be achieved by offering effective screening tests, such as faecal immunochemical tests, flexible sigmoidoscopy and colonoscopy, in organised screening programmes which have been implemented in an increasing number of countries. Countries with early and high uptake rates of effective screening have exhibited major declines in CRC incidence and mortality, in contrast to most other countries. Finally, increasing evidence shows that the prognosis and quality of life of CRC patients can be substantially improved by tertiary prevention measures, such as the administration of low-dose aspirin and the promotion of physical activity.This publication has 98 references indexed in Scilit:
- Superior diagnostic performance of faecal immunochemical tests for haemoglobin in a head-to-head comparison with guaiac based faecal occult blood test among 2235 participants of screening colonoscopyEuropean Journal of Cancer, 2013
- Colorectal-Cancer Incidence and Mortality with Screening Flexible SigmoidoscopyThe New England Journal of Medicine, 2012
- Once-Only Sigmoidoscopy in Colorectal Cancer Screening: Follow-up Findings of the Italian Randomized Controlled Trial--SCOREJNCI Journal of the National Cancer Institute, 2011
- Menopausal hormone therapy and risk of gastrointestinal cancer: Nested case–control study within a prospective cohort, and meta‐analysisInternational Journal of Cancer, 2011
- Cost-effectiveness of Colorectal Cancer ScreeningEpidemiologic Reviews, 2011
- Nicotine Enhances Colon Cancer Cell Migration by Induction of FibronectinAnnals of Surgical Oncology, 2011
- Molecular pathological epidemiology of colorectal neoplasia: an emerging transdisciplinary and interdisciplinary fieldGut, 2010
- Screening for colorectal cancer: randomised trial comparing guaiac-based and immunochemical faecal occult blood testing and flexible sigmoidoscopyGut, 2009
- Cigarettes smoking habit may reduce benefit from cetuximab-based treatment in advanced colorectal cancer patientsExpert Opinion on Biological Therapy, 2009
- Smoking and Colorectal CancerJAMA, 2008