Practice effects due to serial cognitive assessment: Implications for preclinical Alzheimer's disease randomized controlled trials
Top Cited Papers
Open Access
- 1 March 2015
- journal article
- cognitive and-behavioral-assessment
- Published by Wiley in Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
- Vol. 1 (1), 103-111
- https://doi.org/10.1016/j.dadm.2014.11.003
Abstract
Introduction Practice effects are characteristic of nearly all standard cognitive tasks when repeated during serial assessments and are frequently important confounders in clinical trials. Methods We summarize evidence that gains in neuropsychological test performance scores associated with practice effects occur as artifactual changes associated with serial testing within clinical trials. We identify and emphasize such gains in older, non–cognitively impaired individuals and estimate an effect size of 0.25 for composite cognitive measures in older populations assessed three times in a 6‐ to 12‐month period. Results We identified three complementary approaches that can be used to attenuate practice effects: (1) massed practice in a prebaseline period to reduce task familiarity effects; (2) tests designed to reduce practice‐related gains so that item‐specific driven improvements are minimized by using tasks that minimize strategy and/or maximize interitem interference; and (3) well‐matched alternate forms. Discussion We have drawn attention to and increased awareness of practice effect–related gains that could result in type 1 or type 2 errors in trials. Successfully managing practice effects will eliminate a large source of error and reduce the likelihood of misinterpretation of clinical trials outcomes.Keywords
Funding Information
- National Institute on Aging (3R01 AG038734)
- U.S. Department of Defense (W81XWH‐12‐1‐0084)
- National Institutes of Health (P50 AG05142, R01 AG033288, R01 AG037561, UF1 AG046148)
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