No Mutations in CACNA1A and ATP1A2 in Probands With Common Types of Migraine

Abstract

Hemiplegic migraine is a unique migraine syndrome characterized by episodes of hemiplegia and hemianesthesia followed by headache.¹ It can occur in families as an autosomal dominant trait but can also occur sporadically.² Within well-documented families with hemiplegic migraine, some members have only migraine without aura (MO) or migraine with aura (MA). In addition, patients with hemiplegic migraine (familial and sporadic) will often have other brainstem and cerebellar symptoms; there appears to be an overlap between the clinical features of hemiplegic migraine and basilar migraine.³ Linkage studies in large families with hemiplegic migraine have clearly documented genetic heterogeneity.⁴