Therapeutic Success of the Ketogenic Diet as a Treatment Option for Epilepsy: a Meta-analysis
Open Access
- 1 December 2013
- journal article
- review article
- Vol. 23 (6), 613-620
Abstract
To systematically evaluate therapeutic success of the ketogenic diet (KD) as a treatment option for epilepsy. Using MEDLINE and Google Scholar search, we searched for studies investigating the therapeutic success of ketogenic diet for epilepsy. We estimated therapeutic success rate for ketogenic diet as a treatment option for epilepsy and its 95% CIs using generic inverse variance method. A total of 38 studies met the inclusion criteria. In retrospective studies, the weighted success rate of the patients who take the KD as a treatment option for epilepsy was 58.4% (95% confidence interval (95%CI)=48.7% – 69.9%) at 3 months (n=336); 42.8% (95%CI =36.3% – 50.3%) at 6 months (n=492), and 30.1% (95%CI =24.3% – 37.2%) at 12 months (n=387); in prospective studies, weighted success rate was 53.9% (95%CI 45.5% – 63.8%) at 3 months (n=474); 53.2% (95%CI =44.0% – 64.2%) at 6 months (n=321), and 55.0% (95%CI =45.9% – 65.9%) at 12 months (n=347). This meta-analysis provides formal statistical support for the efficacy of the ketogenic diet in the treatment of epileptic patients.Keywords
This publication has 42 references indexed in Scilit:
- Dietary therapies for epilepsy: Future researchEpilepsy & Behavior, 2011
- Nonpharmacologic treatments of Dravet syndrome: Focus on the ketogenic dietEpilepsia, 2011
- Efficacy and tolerability of the Modified Atkins Diet in adults with pharmacoresistant epilepsy: A prospective observational studyEpilepsia, 2011
- Effectiveness of the ketogenic diet in a broad range of seizure types and EEG features for severe childhood epilepsiesActa Neurologica Scandinavica, 2009
- The Ketogenic Diet: Additional Information From a Crossover StudyJournal of Child Neurology, 2009
- A case‐control evaluation of the ketogenic diet versus ACTH for new‐onset infantile spasmsEpilepsia, 2008
- Efficacy and Tolerability of the Ketogenic Diet According to Lipid:Nonlipid Ratios—Comparison of 3:1 with 4:1 DietEpilepsia, 2007
- Ketogenic diet for treatment of infantile spasmsBrain & Development, 2006
- The Outcome of Children with Intractable Seizures: A 3‐ to 6‐Year Follow‐up of 67 Children Who Remained on the Ketogenic Diet Less Than One YearEpilepsia, 2006
- The ketogenic diet in refractory childhood epilepsyJournal of Paediatrics and Child Health, 2005