Two pyridinium metabolites of haloperidol are present in the brain of patients at post-mortem
- 17 January 1997
- journal article
- Published by Elsevier BV in Life Sciences
- Vol. 60 (8), 529-534
- https://doi.org/10.1016/s0024-3205(96)00656-x
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- Haloperidol and its tetrahydropyridine derivative (HPTP) are metabolized to potentially neurotoxic pyridinium species in the baboonLife Sciences, 1996
- Formation of pyridinium species of haloperidol in human liver and brainPsychopharmacology, 1996
- Studies on the metabolism of haloperidol (HP): The role of CYP3A in the production of the neurotoxic pyridinium metabolite HPP+ found in rat brain following ip administration of HPLife Sciences, 1995
- Metabolic Studies on Haloperidol and Its Tetrahydropyridine Analog in C57BL/6 MiceChemical Research in Toxicology, 1994
- Advances in Our Understanding of the Mechanisms of the Neurotoxicity of MPTP and Related CompoundsJournal of Neurochemistry, 1993
- Identification of potentially neurotoxic pyridinium metabolite in the urine of schizophrenic patients treated with haloperidolBiochemical and Biophysical Research Communications, 1991
- Studies on the in vitro conversion of haloperidol to a potentially neurotoxic pyridinium metaboliteChemical Research in Toxicology, 1991
- Carrier-mediated transport in the hepatic distribution and elimination of drugs, with special reference to the category of organic cationsJournal of Pharmacokinetics and Biopharmaceutics, 1990
- Identification of a potentially neurotoxic pyridinium metabolite of haloperidol in ratsBiochemical and Biophysical Research Communications, 1990
- Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomesBiochemical and Biophysical Research Communications, 1985