Normal values and differences between intraperitoneal and subcutaneous microdialysis in patients after non‐complicated gastrointestinal surgery
- 1 June 2005
- journal article
- research article
- Published by Taylor & Francis Ltd in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 65 (4), 273-282
- https://doi.org/10.1080/00365510510013802
Abstract
Objective. Visceral ischemia is an early event in the development of shock and organ failure. Microdialysis has been presented as a promising method for detection of visceral hypoxia and ischemia. The aim of this study was to investigate differences in the metabolic response measured by microdialysis between intraperitoneal and subcutaneous locations and to estimate normal values of lactate/pyruvate ratio, glucose and glycerol. Material and methods. Intraperitoneal and subcutaneous metabolic responses were compared regarding lacate/pyruvate ratio, glucose and glycerol, during 45 postoperative hours in 33 patients undergoing various non‐complicated elective major gastrointestinal surgery. Results. Intraperitoneal lactate/pyruvate ratio started around 15 and decreased over time, while subcutaneous levels were stable around 9. Glucose levels were higher intraperitoneally and increased rapidly during the first 9 h to 8.6 mM, while the subcutaneous levels increased during 21 h to 7.5 mM. Intraperitoneal glycerol levels were stable around 100 µM, while subcutaneous values started around 230 µM and then increased. Conclusions. In a non‐complicated postoperative course the lactate/pyruvate ratio and glucose levels are higher intraperitoneally, suggesting a higher postoperative intraperitoneal metabolism. Glycerol levels are higher and increase subcutaneously, suggesting increased postoperative energy demand, particularly in the visceral organs, as being responsible for the lipolysis seen in the subcutaneous tissue.Keywords
This publication has 10 references indexed in Scilit:
- Results of intraperitoneal microdialysis depend on the location of the catheterScandinavian Journal of Clinical and Laboratory Investigation, 2004
- Assessment of adipose tissue metabolism by means of subcutaneous microdialysis in patients with sepsis or circulatory failureClinical Physiology and Functional Imaging, 2003
- INTRAPERITONEAL MICRODIALYSIS (IPM)Shock, 2003
- Microdialysate metabolites before, during and after vascular surgery for chronic leg ischaemiaEuropean Journal of Vascular and Endovascular Surgery, 2003
- Human Intraperitoneal Microdialysis: Increased Lactate/Pyruvate Ratio Suggests Early Visceral IschaemiaScandinavian Journal of Gastroenterology, 2003
- Experimental Pancreatitis Causes Acute Perturbation of Energy Metabolism in the Intestinal WallPancreas, 2002
- Subcutaneous microdialysis for metabolic monitoring in abdominal aortic surgery.Journal of Clinical Monitoring and Computing, 2002
- Spinal Cord Metabolism During Thoracic Aortic Cross-clamping in Pigs with Special Reference to the Effect of AllopurinolEuropean Journal of Vascular and Endovascular Surgery, 2001
- Splanchnic ischaemia and its role in multiple organ failureActa Anaesthesiologica Scandinavica, 1994
- Microdialysis—principles and applications for studies in animals and manJournal of Internal Medicine, 1991