In-vivo high resolution imaging of optic nerve head drusen using spectral-domain Optical Coherence Tomography
Open Access
- 7 June 2010
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Medical Imaging
- Vol. 10 (1), 11
- https://doi.org/10.1186/1471-2342-10-11
Abstract
Background Optic nerve head drusen (ONHD) are white calcareous deposits, seen either superficially on the optic nerve head or buried within it. Diagnosis of ONHD is made by one or more ways: clinical exam, autofluorescence, ultrasound of the optic nerve, CT scan and/or visual field examination. The present study describes features of ONHD based on another diagnostic modality, the spectral-domain OCT (Spectralis). Methods This is a retrospective case series of 5 patients with bilateral ONHD with a best-corrected visual acuity of 20/20 and no other posterior segment pathology. All the patients underwent fundus photography, fundus autofluorescence, B-scan ultrasonography, Spectralis OCT and Humphrey 30-2 threshold visual fields. Results All 5 patients had surface ONHD which were autofluorescent and echodense on B-scan ultrasonography. Spectralis OCT findings in the corresponding areas include 'scattered spots with high reflectivity' casting a shadow underneath. The reflectivity can be distinctly differentiated from the blood vessels on the optic nerve. Two patients had an arcuate scotoma on the Humphrey visual fields. No correlation was found between the changes on Spectralis OCT with that of visual field. Conclusions Spectralis OCT is another useful ancillary investigation in the diagnosis of ONHD and we describe the features in the present study.Keywords
This publication has 9 references indexed in Scilit:
- Fourier-Domain Optical Coherence Tomography and Adaptive Optics Reveal Nerve Fiber Layer Loss and Photoreceptor Changes in a Patient With Optic Nerve DrusenJournal of Neuro-Ophthalmology, 2008
- Changes in Cellular Structures Revealed by Ultra-high Resolution Retinal Imaging in Optic NeuropathiesPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2008
- CORRELATION OF PATHOLOGIC FEATURES IN SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY WITH CONVENTIONAL RETINAL STUDIESRetina, 2008
- High-Definition and 3-dimensional Imaging of Macular Pathologies with High-speed Ultrahigh-Resolution Optical Coherence TomographyOphthalmology, 2006
- Visual Field Defects and Retinal Nerve Fiber Layer Defects in Eyes With Buried Optic Nerve DrusenAmerican Journal of Ophthalmology, 2006
- Visual Manifestations of Visible and Buried Optic Disc DrusenJournal of Neuro-Ophthalmology, 2004
- Optic Disk DrusenSurvey of Ophthalmology, 2002
- Evaluation of Coexisting Optic Nerve Head Drusen and Glaucoma with Optical Coherence TomographyOphthalmology, 1997
- Pathology and Pathogenesis of Drusen of the Optic NerveheadOphthalmology, 1981