Lipid-cytokine-chemokine cascades orchestrate leukocyte recruitment in inflammation
Open Access
- 4 November 2011
- journal article
- review article
- Published by Oxford University Press (OUP) in Journal of Leukocyte Biology
- Vol. 91 (2), 207-215
- https://doi.org/10.1189/jlb.0811402
Abstract
Chemoattractants are pivotal mediators of host defense, orchestrating the recruitment of immune cells into sites of infection and inflammation. Chemoattractants display vast chemical diversity and include bioactive lipids, proteolytic fragments of serum proteins, and chemokines (chemotactic cytokines). All chemoattractants induce chemotaxis by activating seven-transmembrane-spanning GPCRs expressed on immune cells, establishing the concept that all chemoattractants are related in function. However, although chemoattractants have overlapping functions in vitro, recent in vivo data have revealed that they function, in many cases, nonredundantly in vivo. The chemically diverse nature of chemoattractants contributes to the fine control of leukocyte trafficking in vivo, with sequential chemoattractant use guiding immune cell recruitment into inflammatory sites. Lipid mediators frequently function as initiators of leukocyte recruitment, attracting the first immune cells into tissues. These initial responding immune cells produce cytokines locally, which in turn, induce the local release of chemokines. Local chemokine production then markedly amplifies subsequent waves of leukocyte recruitment. These new discoveries establish a paradigm for leukocyte recruitment in inflammation—described as lipid-cytokine-chemokine cascades—as a driving force in the effector phase of immune responses.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft
- Arthritis Foundation
- NIH
This publication has 122 references indexed in Scilit:
- The Structure of Human 5-LipoxygenaseScience, 2011
- Lipid-Cytokine-Chemokine Cascade Drives Neutrophil Recruitment in a Murine Model of Inflammatory ArthritisImmunity, 2010
- The platelet activating factor (PAF) signaling cascade in systemic inflammatory responsesBiochimie, 2010
- CRTH2 expression on T cells in asthmaClinical and Experimental Immunology, 2010
- Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle ProductionScience, 2010
- 5-Oxo-ETE and the OXE receptorProstaglandins & Other Lipid Mediators, 2009
- Innate Cells and T Helper 2 Cell Immunity in Airway InflammationImmunity, 2009
- Contribution of CCR4 and CCR8 to antigen-specific TH2 cell trafficking in allergic pulmonary inflammationJournal of Allergy and Clinical Immunology, 2009
- 12(S)-hydroxyheptadeca-5Z, 8E, 10E–trienoic acid is a natural ligand for leukotriene B4 receptor 2The Journal of Experimental Medicine, 2008
- Mast cells contribute to initiation of autoantibody-mediated arthritis via IL-1Proceedings of the National Academy of Sciences of the United States of America, 2007