Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex
- 8 April 2007
- journal article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 10 (5), 549-551
- https://doi.org/10.1038/nn1883
Abstract
Determining the degree of synapse formation and elimination is essential for understanding the structural basis of brain plasticity and pathology. We show that in vivo imaging of dendritic spine dynamics through an open-skull glass window, but not a thinned-skull window, is associated with high spine turnover and substantial glial activation during the first month after surgery. These findings help to explain existing discrepancies in the degree of dendritic spine plasticity observed in the mature cortex.Keywords
This publication has 15 references indexed in Scilit:
- Experience-dependent and cell-type-specific spine growth in the neocortexNature, 2006
- Signaling between glia and neurons: focus on synaptic plasticityCurrent Opinion in Neurobiology, 2005
- Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortexNature, 2005
- Development of Long-Term Dendritic Spine Stability in Diverse Regions of Cerebral CortexNeuron, 2005
- Transient and Persistent Dendritic Spines in the Neocortex In VivoNeuron, 2005
- Brain Imaging: How Stable Are Synaptic Connections?Current Biology, 2003
- How hardwired is the brain?Nature, 2002
- Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortexNature, 2002
- Long-term dendritic spine stability in the adult cortexNature, 2002
- Microglial-neuronal interactions in synaptic damage and recoveryJournal of Neuroscience Research, 1999