Potential and problems in ultrasound-responsive drug delivery systems
Open Access
- 1 April 2013
- journal article
- review article
- Published by Taylor & Francis Ltd in International Journal of Nanomedicine
- Vol. ume 8 (1), 1621-1633
- https://doi.org/10.2147/ijn.s43589
Abstract
Ultrasound is an important local stimulus for triggering drug release at the target tissue. Ultrasound-responsive drug delivery systems (URDDS) have become an important research focus in targeted therapy. URDDS include many different formulations, such as microbubbles, nanobubbles, nanodroplets, liposomes, emulsions, and micelles. Drugs that can be loaded into URDDS include small molecules, biomacromolecules, and inorganic substances. Fields of clinical application include anticancer therapy, treatment of ischemic myocardium, induction of an immune response, cartilage tissue engineering, transdermal drug delivery, treatment of Huntington’s disease, thrombolysis, and disruption of the blood–brain barrier. This review focuses on recent advances in URDDS, and discusses their formulations, clinical application, and problems, as well as a perspective on their potential use in the future.This publication has 102 references indexed in Scilit:
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