Systemic Immune Response to Vaccination on FDG-PET/CT
- 9 December 2015
- journal article
- Published by Springer Science and Business Media LLC in Nuclear Medicine and Molecular Imaging
- Vol. 50 (4), 358-361
- https://doi.org/10.1007/s13139-015-0385-6
Abstract
A patient with newly diagnosed right lung cancer had transient 18F-fluorodeoxyglucose (FDG)-avid left axillary lymph nodes and intense splenic FDG uptake on positron emission tomography (PET)/computed tomography (CT). History revealed that the patient received a left-sided influenza vaccine 2–3 days before the examination. Although inflammatory FDG uptake in ipsilateral axillary nodes is reported, to our knowledge, this is the first report of visualization of the systemic immune response in the spleen related to the influenza vaccination on FDG-PET/CT. The history, splenic uptake and time course on serial FDG-PET/CT helped to avoid a false-positive interpretation for progressing lung cancer and alteration of the radiation therapy plan.Keywords
This publication has 14 references indexed in Scilit:
- Duration of 18F-FDG avidity in lymph nodes after pandemic H1N1v and seasonal influenza vaccinationEuropean Journal of Nuclear Medicine and Molecular Imaging, 2011
- Intense FDG uptake in the spleen due to recent granulocyte-macrophage colony-stimulating factor administration: Follow-up scan clarifying the situationJournal of Cancer Research and Therapeutics, 2011
- The Clinical Implication and Prediction of Diffuse Splenic FDG Uptake During Cancer SurveillanceClinical Nuclear Medicine, 2010
- FDG uptake in axillary lymph nodes after vaccination against pandemic (H1N1)European Radiology, 2010
- High F-18 FDG Uptake in Bone Marrow by Cytokines Secreting Ectopic Mucoepidermoid CarcinomaClinical Nuclear Medicine, 2009
- Clinical significance of diffusely increased splenic uptake on FDG-PETNuclear Medicine Communications, 2009
- Analysis of 18F-FDG PET diffuse bone marrow uptake and splenic uptake in staging of Hodgkin’s lymphoma: a reflection of disease infiltration or just inflammation?European Journal of Nuclear Medicine and Molecular Imaging, 2009
- 18F-FDG-PET/CT findings of granulocyte colony stimulating factor (G-CSF)-producing lung tumorsAnnals of Nuclear Medicine, 2008
- False-Positive Axillary Lymph Node on FDG-PET/CT Scan Resulting From ImmunizationClinical Nuclear Medicine, 2006
- Splenic fluorodeoxyglucose uptake increased by granulocyte colony-stimulating factor therapy: PET imaging results.1999