Association of C-type lectin 18 levels with extrahepatic manifestations in chronic HCV infection
Open Access
- 23 November 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 8 (1), 17287
- https://doi.org/10.1038/s41598-018-35774-w
Abstract
Mixed cryobulinemia (MC) is the most common chronic hepatitis C virus (HCV)-associated extrahepatic manifestation. C-type lectin 18 (CLEC18) is a novel secretory lectin that is abundantly expressed in hepatocytes and peripheral blood cells (PBCs). We investigated the associations between CLEC18 expression during HCV infection and the presence of extrahepatic manifestations. A total of 41 rheumatic patients with HCV infection (including 28 patients with MC syndrome), 45 rheumatic patients without infection, and 14 healthy subjects were enrolled. The CLEC18 levels in PBCs and serum were determined by using flow cytometry and enzyme-linked immunosorbent assay, respectively. Significantly higher CLEC18 levels were observed in patients with HCV infection (P < 0.001) and were positively correlated with HCV viral loads (gamma = 0.56, P < 0.05). Among patients with HCV infection, significantly increased CLEC18 levels were observed in patients with MC syndrome, particularly in those with type II MC (P < 0.05). CLEC18 levels were associated with cryoglobulin and C4 levels (P < 0.05). CLEC18 was significantly associated with HCV infection, particularly in those with HCV-associated MC. CLEC18 levels were also positively correlated with MC disease activity, suggesting its involvement in MC pathogenesis. CLEC18 may be a novel indicator of HCV infection and a potential therapeutic target in rheumatic patients.Funding Information
- Academia Sinica (VTA105V2-1-2, VTA106V2-1-2, VTA107V2-1-2)
This publication has 41 references indexed in Scilit:
- C-type lectins in immunity and homeostasisNature Reviews Immunology, 2018
- CLEC5A-Mediated Enhancement of the Inflammatory Response in Myeloid Cells Contributes to Influenza Virus Pathogenicity In VivoJournal of Virology, 2017
- Neutrophil cell surface receptors and their intracellular signal transduction pathwaysInternational Immunopharmacology, 2013
- The Role of Humoral Innate Immunity in Hepatitis C Virus InfectionViruses, 2012
- 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiativeAnnals Of The Rheumatic Diseases, 2010
- CLEC5A is critical for dengue-virus-induced lethal diseaseNature, 2008
- Mannan binding lectin and its interaction with immunoglobulins in health and in diseaseImmunology Letters, 2006
- Secular trends and geographic variations of hepatitis B virus and hepatitis C virus‐associated hepatocellular carcinoma in TaiwanInternational Journal of Cancer, 2006
- Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus GroupAnnals Of The Rheumatic Diseases, 2002
- Updating the American college of rheumatology revised criteria for the classification of systemic lupus erythematosusArthritis & Rheumatism, 1997