Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation
- 3 September 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 329 (5996), 1201-1205
- https://doi.org/10.1126/science.1191241
Abstract
Regulation of Energy Homeostasis: The mammalian AMP-activated protein kinase (AMPK) is a serine/threonine kinase complex that regulates cellular energy homeostasis. However, the mechanisms by which AMPK mediates transcriptional responses to metabolic perturbations has been unclear. Bungard et al. (p. 1201 ; published online 17 August; see the Perspective by Hardie ) have found that AMPK activated transcription directly on chromatin, combined with phosphorylation of histone H2B at Serine-36. Both signals colocalized at genes regulated in the pathway, and both the enzyme and phosphorylation were required for the direct transcription of stress-responsive genes.Keywords
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