The Effect of Aspirin Intake on Bleeding on Probing in Patients With Gingivitis
- 1 May 2004
- journal article
- research article
- Published by Wiley in The Journal of Periodontology
- Vol. 75 (5), 679-684
- https://doi.org/10.1902/jop.2004.75.5.679
Abstract
Bleeding indices are used as a screen for periodontal disease activity, a measure of disease prevalence, and a measure of effectiveness in clinical trials. Bleeding on probing (BOP) is widely interpreted as a sign of disease activity whereas its absence is interpreted as both a sign and predictor of health. Aspirin use has become increasingly common in the prevention of cerebrovascular and cardiovascular diseases. Because of its anti-platelet activity, aspirin is a non-disease factor that has the potential to affect the appearance of BOP. The hypothesis being tested is that short-term aspirin use in doses of 81 mg and 325 mg will increase the number of bleeding sites in a population with gingivitis. Fifty-four subjects were screened initially, those subjects with 20% to 30% whole mouth BOP were randomly assigned to one of three arms: placebo group, 81 mg aspirin group, or 325 mg aspirin group. Before and after exposure to the respective regimens, clinical parameters were measured on all the teeth: the plaque index was recorded at four sites per tooth, and probing depth and BOP were evaluated at six sites per tooth using an automated pressure-sensitive probe. The data obtained in this clinical trial were analyzed utilizing a linear regression analysis to control for confounding variables. The primary measure of interest was BOP in patients clinically demonstrating naturally occurring gingivitis. The results of this study indicate that while controlling for age, gender, and plaque, "low dose" 81 mg and "regular dose" 325 mg of aspirin demonstrated a statistically significant 5.30 (P = 0.001) and 4.13 (P = 0.010) increase from baseline, respectively, in percent BOP. Failure to consider the effects of aspirin on BOP could impair proper diagnosis and treatment planning for clinicians and introduce a significant confounding variable in research situations.Keywords
This publication has 9 references indexed in Scilit:
- The Effect of Aspirin on the Periodontal Parameter Bleeding on ProbingThe Journal of Periodontology, 2002
- Gingival Recession, Gingival Bleeding, and Dental Calculus in Adults 30 Years of Age and Older in the United States, 1988‐1994The Journal of Periodontology, 1999
- Effects of very low dose and enteric-coated acetylsalicylic acid on prostacyclin and thromboxane formation and on bleeding time in healthy subjectsEuropean Journal of Clinical Pharmacology, 1998
- Aspirin as a Therapeutic Agent in Cardiovascular DiseaseCirculation, 1997
- The effect of systemically-administered flurbiprofen as an adjunct to toothbrushing on the resolution of experimental gingivitisJournal of Clinical Periodontology, 1994
- The Role of Bleeding upon Probing in the Diagnosis of Periodontal Disease: A Literature ReviewThe Journal of Periodontology, 1984
- AN ORAL HYGIENE MEASUREMENT SYSTEM FOR POSSIBLE RESEARCH AND CLINICAL USEJournal of Public Health Dentistry, 1975
- Experimental Gingivitis in ManThe Journal of Periodontology, 1965
- Periodontal Disease: Prevalence and IncidenceThe Journal of Periodontology, 1955