Diagnosis of Zika virus infection on a nanotechnology platform
- 6 March 2017
- journal article
- Published by Springer Science and Business Media LLC in Nature Medicine
- Vol. 23 (5), 548-550
- https://doi.org/10.1038/nm.4302
Abstract
We developed a multiplexed assay on a plasmonic-gold platform for measuring IgG and IgA antibodies and IgG avidity against both Zika virus (ZIKV) and dengue virus (DENV) infections. In contrast to IgM cross-reactivity, IgG and IgA antibodies against ZIKV nonstructural protein 1 (NS1) antigen were specific to ZIKV infection, and IgG avidity revealed recent ZIKV infection and past DENV-2 infection in patients in dengue-endemic regions. This assay could enable specific diagnosis of ZIKV infection over other flaviviral infections.Keywords
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