The CYP4A Isoforms Hydroxylate Epoxyeicosatrienoic Acids to Form High Affinity Peroxisome Proliferator-activated Receptor Ligands
Open Access
- 1 September 2002
- journal article
- Published by Elsevier BV in Journal of Biological Chemistry
- Vol. 277 (38), 35105-35112
- https://doi.org/10.1074/jbc.m201575200
Abstract
No abstract availableKeywords
This publication has 55 references indexed in Scilit:
- Structural Determination of the Substrate Specificities and Regioselectivities of the Rat and Human Fatty Acid ω-HydroxylasesArchives of Biochemistry and Biophysics, 2000
- Molecular Mechanisms of Cytochrome P-450 Induction by Xenobiotics: An Expanded Role for Nuclear Hormone ReceptorsPublished by American Society for Pharmacology & Experimental Therapeutics (ASPET) ,1999
- P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPARArchives of Biochemistry and Biophysics, 1999
- Peroxisome Proliferator-activated Receptor α Controls the Hepatic CYP4A Induction Adaptive Response to Starvation and DiabetesJournal of Biological Chemistry, 1998
- Molecular, Enzymatic, and Regulatory Characterization of Rat Kidney Cytochromes P450 4A2 and 4A3Biochemistry, 1998
- Cloning, Sequencing, and cDNA-Directed Expression of the Rat Renal CYP4A2: Arachidonic Acid ω-Hydroxylation and 11,12-Epoxidation by CYP4A2 ProteinArchives of Biochemistry and Biophysics, 1996
- Role of the peroxisome proliferator‐activated receptor in cytochrome P450 4A gene regulationThe FASEB Journal, 1996
- Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome ProliferatorsMolecular and Cellular Biology, 1995
- Regulation of cytochrome P450 genes: molecular mechanismsPharmacogenetics, 1993
- Cloning and Characterization of a Novel Member of the Cytochrome P450 Subfamily IVA in Rat ProstateDNA and Cell Biology, 1990