Development of coronary atherosclerosis in swine with severe hypercholesterolemia. Lack of influence of von Willebrand factor or acute intimal injury.
- 1 March 1986
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Vol. 6 (2), 155-165
- https://doi.org/10.1161/01.atv.6.2.155
Abstract
The development of coronary atherosclerosis in response to acute intimal injury and severe hypercholesterolemia was studied in 18 swine, nine normal and nine with von Willebrand's disease, an inherited disorder affecting platelet-vessel wall interactions. The left anterior descending coronary artery was denuded of endothelium by balloon catheterization, while the circumflex and right coronary arteries served as nonballooned controls. All swine were maintained on a 2% cholesterol diet for 4 months. The extent of atherosclerotic involvement was evaluated from four indices: percent intimal area, percent luminal narrowing, ratio of intimal to medial area, and luminal form. No differences in coronary atherosclerosis were observed between phenotypes in either ballooned or nonballooned vessels, nor were there any differences between ballooned and nonballooned vessels within either phenotype (p greater than 0.05). The major variable affecting coronary atherosclerosis was serum cholesterol. There was a significant positive relationship between serum cholesterol concentration and the extent of intimal lesions (r = 0.62, p = 0.006) that was independent of plasma von Willebrand factor concentration. These findings suggest that severe hypercholesterolemia promotes the development of porcine coronary atherosclerosis through a mechanism(s) that is independent of acute intimal injury or von Willebrand factor-mediated platelet response to injury.This publication has 28 references indexed in Scilit:
- Spontaneous and diet-induced coronary atherosclerosis in normal swine and swine with von Willebrand disease.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Regulation of production of a platelet‐derived growth factor‐like protein by cultured bovine aortic endothelial cellsJournal of Cellular Physiology, 1984
- Studies of hypercholesterolemia in the nonhuman primate. II. Fatty streak conversion to fibrous plaque.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
- Studies of hypercholesterolemia in the nonhuman primate. I. Changes that lead to fatty streak formation.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
- Ultrastructure of experimental coronary artery atherosclerosis in cynomolgus macaquesAtherosclerosis, 1982
- An endothelial cell-derived growth factor.The Journal of cell biology, 1980
- Arterial platelet accumulation in experimental hypercholesterolemiaAtherosclerosis, 1980
- Resistance to Arteriosclerosis in Pigs with von Willebrand's DiseaseJCI Insight, 1978
- The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.JCI Insight, 1977
- Hyperlipidemia and AtherosclerosisScience, 1976