Changes in muscle T2 and tissue damage after downhill running in mdx Mice
- 12 April 2011
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 43 (6), 878-886
- https://doi.org/10.1002/mus.21986
Abstract
Introduction: In this study we compared the effects of downhill or horizontal treadmill running on the magnetic resonance imaging (MRI) transverse relaxation time constant (T2) in mdx mice. Methods: Mice underwent either downhill (n = 11 mdx, n = 6 controls) or horizontal running (n = 9, mdx only) on a treadmill. MRI was conducted prior to exercise, immediately afterward (∽20 minutes), and then 24 and 48 hours after exercise. Results: A higher percentage of pixels with elevated T2 in the lower hindlimb muscles was observed in the mdx mice compared with controls both pre‐exercise (P < 0.001) and at each time‐point after downhill running (P < 0.05), but not with horizontal running. The medial compartment muscles appeared to be the most susceptible to increased T2. Conclusions: Downhill running provides a stimulus for inducing acute changes in muscle T2 in mdx mice. MRI is a non‐invasive approach for examining acute muscle damage and recovery in multiple muscle groups simultaneously. Muscle Nerve, 2010.Keywords
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