A Neural Network Model of Chemotaxis Predicts Functions of Synaptic Connections in the Nematode Caenorhabditis elegans
- 1 September 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Journal of Computational Neuroscience
- Vol. 17 (2), 137-147
- https://doi.org/10.1023/b:jcns.0000037679.42570.d5
Abstract
The anatomical connectivity of the nervous system of the nematode Caenorhabditis elegans has been almost completely described, but determination of the neurophysiological basis of behavior in this system is just beginning. Here we used an optimization algorithm to search for patterns of connectivity sufficient to compute the sensorimotor transformation underlying C. elegans chemotaxis, a simple form of spatial orientation behavior in which turning probability is modulated by the rate of change of chemical concentration. Optimization produced differentiator networks capable of simulating chemotaxis. A surprising feature of these networks was inhibitory feedback connections on all neurons. Further analysis showed that feedback regulates the latency between sensory input and behavior. Common patterns of connectivity between the model and biological networks suggest new functions for previously identified connections in the C. elegans nervous system.Keywords
This publication has 15 references indexed in Scilit:
- The Fundamental Role of Pirouettes inCaenorhabditis elegansChemotaxisJournal of Neuroscience, 1999
- Neuronal Control of Locomotion in C. elegans Is Modified by a Dominant Mutation in the GLR-1 Ionotropic Glutamate ReceptorNeuron, 1999
- [13] Tight-seal whole-cell patch clamping of caenorhabditis elegans neuronsMethods in Enzymology, 1998
- Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegansNeuron, 1991
- Signaling properties of Ascaris motorneurons: graded active responses, graded synaptic transmission, and tonic transmitter releaseJournal of Neuroscience, 1989
- Passive membrane properties of motorneurons and their role in long- distance signaling in the nematode AscarisJournal of Neuroscience, 1989
- The structure of the nervous system of the nematodeCaenorhabditis elegansPhilosophical Transactions of the Royal Society of London. B, Biological Sciences, 1986
- The neural circuit for touch sensitivity in Caenorhabditis elegansJournal of Neuroscience, 1985
- Wave Forms of Caenorhabditis elegans in a Chemical Attractant and Repellent and in Thermal Gradients.1979
- Electron microscopical reconstruction of the anterior sensory anatomy of the nematode caenorhabditis elegansJournal of Comparative Neurology, 1975