Understanding diabetic teratogenesis: Where are we now and where are we going?
- 12 August 2010
- journal article
- review article
- Published by Wiley in Birth Defects Research Part A: Clinical and Molecular Teratology
- Vol. 88 (10), 779-790
- https://doi.org/10.1002/bdra.20704
Abstract
Maternal pregestational diabetes (type 1 or type 2) poses an increased risk for a broad spectrum of birth defects. To our knowledge, this problem first came to the attention of the Teratology Society at the 14th Annual Meeting in Vancouver, B.C. in 1974, with a presentation by Lewis Holmes, “Etiologic heterogeneity of neural tube defects”. Although advances in the control of diabetes in the decades since the discovery of insulin in the 1920's have reduced the risk for birth defects during diabetic pregnancy, the increasing incidence of diabetes among women of childbearing years indicates that this cause of birth defects is a growing public health concern. Major advances in understanding how a disease of maternal fuel metabolism can interfere with embryogenesis of multiple organ systems have been made in recent years. In this review, we trace the history of the study of diabetic teratogenesis and discuss a model in which tissue‐specific developmental control genes are regulated at specific times in embryonic development by glucose metabolism. The major function of such genes is to suppress apoptosis, perhaps to preserve proliferative capability, and inhibit premature senescence. Birth Defects Research (Part A), 2010.Keywords
This publication has 133 references indexed in Scilit:
- Fetal Anomalies in Obese WomenObstetrics & Gynecology, 2010
- Maternal diabetes alters transcriptional programs in the developing embryoBMC Genomics, 2009
- Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crestMechanisms of Development, 2008
- Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular developmentCardiovascular Diabetology, 2007
- Abnormal blood vessel development and lethality in embryos lacking a single VEGF alleleNature, 1996
- Incidence of Spontaneous Abortion among Normal Women and Insulin-Dependent Diabetic Women Whose Pregnancies Were Identified within 21 Days of ConceptionNew England Journal of Medicine, 1988
- Effect of hyperglycemia on sorbitol and myo-inositol content of cultured rat conceptus: Failure of aldose reductase inhibitors to modify myo-inositol depletion and dysmorphogenesisBiochemical and Biophysical Research Communications, 1986
- Holoprosencephaly in infants of diabetic mothersThe Journal of Pediatrics, 1983
- Elevated Maternal Hemoglobin A1Cin Early Pregnancy and Major Congenital Anomalies in Infants of Diabetic MothersNew England Journal of Medicine, 1981
- On the Origin of Cancer CellsScience, 1956