Bacterial [Cu,Zn]-Cofactored Superoxide Dismutase Protects Opsonized, EncapsulatedNeisseria meningitidisfrom Phagocytosis by Human Monocytes/Macrophages
Open Access
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 71 (3), 1604-1607
- https://doi.org/10.1128/iai.71.3.1604-1607.2003
Abstract
Superoxide dismutase cofactored by copper and zinc ([Cu,Zn]-SOD) contributes to the protection of opsonized serogroup BNeisseria meningitidisagainst phagocytosis by human monocytes/macrophages, withsodCmutant organisms being endocytosed in significantly higher numbers than are wild-type organisms. The influence of [Cu,Zn]-SOD was found to be exerted at the stage of phagocytosis, rather than at earlier (modulating surface association) or later (intracellular killing) stages.Keywords
This publication has 34 references indexed in Scilit:
- Lipid modification of the Cu,Zn superoxide dismutase from Mycobacterium tuberculosisBiochemical Journal, 2001
- Cu,Zn Superoxide Dismutase ofMycobacterium tuberculosisContributes to Survival in Activated Macrophages That Are Generating an Oxidative BurstInfection and Immunity, 2001
- Interactions of Pathogenic Neisseriae with Epithelial Cell MembranesAnnual Review of Cell and Developmental Biology, 2000
- Increased Expression of Periplasmic Cu,Zn Superoxide Dismutase Enhances Survival of Escherichia coli Invasive Strains within Nonphagocytic CellsInfection and Immunity, 2000
- Bacterial copper‐ and zinc‐cofactored superoxide dismutase contributes to the pathogenesis of systemic salmonellosisMolecular Microbiology, 1997
- Meningococcal Opa and Opc proteins: their role in colonization and invasion of human epithelial and endothelial cellsMolecular Microbiology, 1993
- Expression of the Opc protein correlates with invasion of epithelial and endothelial cells by Neisseria meningitidisMolecular Microbiology, 1992
- The role of pili in the interactions of pathogenic Neisseria with cultured human endothelial cellsMolecular Microbiology, 1991
- Studies on the molecular mechanisms of human Fc receptor-mediated phagocytosis. Amplification of ingestion is dependent on the generation of reactive oxygen metabolites and is deficient in polymorphonuclear leukocytes from patients with chronic granulomatous disease.JCI Insight, 1988
- Nonbactericidal Antibodies against Neisseria gonorrhoeae: Evaluation of Their Blocking Effect on Bactericidal Antibodies Directed against Outer Membrane AntigensMicrobiology, 1988