Widespread Divergence Between Incipient Anopheles gambiae Species Revealed by Whole Genome Sequences
- 22 October 2010
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 330 (6003), 512-514
- https://doi.org/10.1126/science.1195755
Abstract
Signals of Mosquito Speciation: Malaria in Africa is transmitted by the mosquito species complex Anopheles gambiae . Neafsey et al. (p. 514 ) made high-resolution single-nucleotide arrays to map genetic divergence among members of the species. Differentiation between populations was observed and evidence obtained for selective sweeps within populations. Most divergence occurred within inversion regions around the centrosome and in genes associated with development, pheromone signaling, and from the X chromosome. The analysis also revealed signals of sympatric speciation occurring within similar chromosomal regions in mosquitoes from different regions in Africa. Lawniczak et al. (p. 512 ) sequenced the genomes of two molecular forms (known as M and S) of A. gambiae , which have distinctive behavioral phenotypes and appear to be speciating. This effort resolves problems arising from the apparently chimeric nature of the reference genome and confirms the observed genome-wide divergences. This kind of analysis has the potential to contribute to control programs that can adapt to population shifts in mosquito behavior arising from the selective effects of the control measures themselves.This publication has 24 references indexed in Scilit:
- SNP Genotyping Defines Complex Gene-Flow Boundaries Among African Malaria Vector MosquitoesScience, 2010
- Genetic association of physically unlinked islands of genomic divergence in incipient species of Anopheles gambiaeMolecular Ecology, 2010
- Tracking footprints of artificial selection in the dog genomeProceedings of the National Academy of Sciences of the United States of America, 2010
- Spatial swarm segregation and reproductive isolation between the molecular forms of Anopheles gambiaeProceedings. Biological sciences, 2009
- Recombination and Speciation: Loci Near Centromeres Are More Differentiated Than Loci Near Telomeres Between Subspecies of the European Rabbit (Oryctolagus cuniculus)Genetics, 2009
- Living at the edge: biogeographic patterns of habitat segregation conform to speciation by niche expansion in Anopheles gambiaeBMC Ecology, 2009
- “REVERSE ECOLOGY” AND THE POWER OF POPULATION GENOMICSEvolution, 2008
- The molecular forms of Anopheles gambiae: A phenotypic perspectiveInfection, Genetics and Evolution, 2008
- Anopheles gambiae complex along The Gambia river, with particular reference to the molecular forms of An. gambiae s.sMalaria Journal, 2008
- Genomic Islands of Speciation in Anopheles gambiaePLoS Biology, 2005