Low incidence of bronchus-associated lymphoid tissue (BALT) in chronically inflamed human lungs
- 1 December 1992
- journal article
- research article
- Published by Springer Science and Business Media LLC in Virchows Archiv B Cell Pathology Including Molecular Pathology
- Vol. 62 (1), 271-274
- https://doi.org/10.1007/bf02899692
Abstract
The relevance of bronchus-associated lymphoid tissue (BALT) in man is still under discussion. Animal experiments indicate that the development of BALT is dependent on microbial stimulation. Therefore, the incidence of BALT was investigated retrospectively in specimens removed during surgical procedures on patients with chronic pulmonary inflammation. All these patients had severe chronic bronchitis and bronchiectasis, but BALT was found in only 8%. In patients with BALT and a malignant tumor, occlusion of a bronchus with poststenotic pneumonia was always present and BALT was observed exclusively in areas peripheral to the occlusion. In man other compartments of the lung must be responsible for the immune function of BALT found in animals.Keywords
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