Peroxynitrite releases copper from caeruloplasmin: implications for atherosclerosis
- 28 March 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 342 (1), 49-52
- https://doi.org/10.1016/0014-5793(94)80582-2
Abstract
Peroxynitrite may be formed in the vasculature by the reaction of puperoxide with nitric oxide. When the blue copper-containing protein, caeruloplasmin, is incubated with peroxynitrite, copper is released, and ferroxidase activity and the blue colouration are lost. When plasma from normal subjects is incubated with peroxynitrite, the oxidant reacts with numerous plasma constituents but is still able to release copper from caeruloplasmin. As the ferroxidase activity of caeruloplasmin is lost in plasma in the presence of peroxynitrite, a second ferroxidase activity associated with peroxidised lipids, and not inhibited by azide, is formed.This publication has 22 references indexed in Scilit:
- Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptorFEBS Letters, 1993
- Hypercholesterolemia increases endothelial superoxide anion production.JCI Insight, 1993
- Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteinsBiochimica et Biophysica Acta (BBA) - General Subjects, 1993
- Role of oxidized low density lipoprotein in atherogenesis.JCI Insight, 1991
- Macrophages and Oxidized Low Density Lipoproteins in the Pathogenesis of AtherosclerosisAnnals of Medicine, 1991
- Continuous Monitoring ofin VztroOxidation of Human Low Density LipoproteinFree Radical Research Communications, 1989
- Macrophage oxidation of low density lipoprotein generates a modified form recognized by the scavenger receptor.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1986
- Age pigments: Role of iron and copper salts in the formation of fluorescent lipid complexesMechanisms of Ageing and Development, 1984
- LIPOPROTEIN METABOLISM IN THE MACROPHAGE: Implications for Cholesterol Deposition in AtherosclerosisAnnual Review of Biochemistry, 1983
- Lipid components of human ferroxidase-IIBiochemical and Biophysical Research Communications, 1973