Strontium Induced Rickets: Metabolic Basis
- 26 November 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 174 (4012), 949-951
- https://doi.org/10.1126/science.174.4012.949
Abstract
Dietary strontium inhibits both the synthesis of 1,25-dihydroxycholecalciferol and intestinal calcium absorption in vitamin D3-repleted chicks. 1,25-Dihydroxycholecalciferol restores calcium absorption to normal, while 25-hydroxycholecalciferol is without effect in the strontium-fed chick. It is suggested that strontium induces rickets by blocking the biosynthesis of 1,25-dihydroxycholecalciferol, the metabolically active form of vitamin D in the intestine.Keywords
This publication has 16 references indexed in Scilit:
- Synthesis of [26,27-3H]-25-hydroxycholecalciferolAnalytical Biochemistry, 1971
- Biological activity 1,25-dihydroxycholecalciferolBiochemistry, 1971
- Vitamin D Metabolism: The Role of Kidney TissueScience, 1971
- Mechanism of Action of 1,25-Dihydroxycholecalciferol on Intestinal Calcium TransportProceedings of the National Academy of Sciences of the United States of America, 1971
- A Rapidly Acting Metabolite of Vitamin D 3Proceedings of the National Academy of Sciences of the United States of America, 1971
- Unique Biosynthesis by Kidney of a Biologically Active Vitamin D MetaboliteNature, 1970
- Strontium Inhibition of Vitamin D3-Induced Calcium-Binding Protein (CaBP) and Calcium Absorption in Chick IntestineExperimental Biology and Medicine, 1970
- The role of the liver in the metabolism of vitamin DJCI Insight, 1969
- The Synthesis of [1,2-3H] Vitamin D3 and the Tissue Localization of a 0.25-μg (10 IU) Dose per Rat*Biochemistry, 1966
- Studies of Incurable Rickets. I. Respective Role of the Local Factor and Vitamin D in HealingExperimental Biology and Medicine, 1934