Obesity and Obesity-Initiated Metabolic Syndrome
Top Cited Papers
Open Access
- 1 May 2007
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Clinical Journal of the American Society of Nephrology
- Vol. 2 (3), 550-562
- https://doi.org/10.2215/cjn.04071206
Abstract
There is an epidemic of obesity and the metabolic syndrome in the United States and across the world. Both entities are associated with high mortality, mainly as a result of cardiovascular disease. The epidemic of obesity has been paralleled by an increase in the incidence of chronic kidney disease (CKD). Several recent epidemiologic studies have shown that obesity and the metabolic syndrome are independent predictors of CKD. In addition to diabetes and hypertension, several other mechanisms have been postulated to initiate and maintain kidney injury in patients with obesity and the metabolic syndrome. This article reviews the recent epidemiologic data linking obesity and the metabolic syndrome to CKD and summarizes the potential mechanisms of renal injury in this setting, with a focus on the role of inflammation, lipotoxicity, and hemodynamic factors. Potential preventive and therapeutic modalities based on the limited evidence available are discussed.Keywords
This publication has 101 references indexed in Scilit:
- LipotoxicityKidney International, 2006
- Prevalence of Overweight and Obesity in the United States, 1999-2004JAMA, 2006
- Associations of Metabolic Syndrome With Inflammation in CKD: Results From the Third National Health and Nutrition Examination Survey (NHANES III)American Journal of Kidney Diseases, 2005
- Left ventricular filling abnormalities and obesity-associated hypertension: relationship with overproduction of circulating transforming growth factor β1Journal of Human Hypertension, 2005
- Association of obesity with inflammation in chronic kidney disease: A cross-sectional studyJournal of Renal Nutrition, 2004
- Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factorsBiochemical Society Transactions, 2004
- Overexpression of Sterol Regulatory Element-binding Protein-1a in Mouse Adipose Tissue Produces Adipocyte Hypertrophy, Increased Fatty Acid Secretion, and Fatty LiverPublished by Elsevier BV ,2003
- Fatty acids exacerbate tubulointerstitial injury in protein-overload proteinuriaAmerican Journal of Physiology-Renal Physiology, 2002
- Body-Mass Index and Mortality in a Prospective Cohort of U.S. AdultsNew England Journal of Medicine, 1999
- The Effect of Weight Reduction on Blood Pressure, Plasma Renin Activity, and Plasma Aldosterone Levels in Obese PatientsNew England Journal of Medicine, 1981