Genotyping over 100,000 SNPs on a pair of oligonucleotide arrays
- 21 October 2004
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 1 (2), 109-111
- https://doi.org/10.1038/nmeth718
Abstract
We present a genotyping method for simultaneously scoring 116,204 SNPs using oligonucleotide arrays. At call rates >99%, reproducibility is >99.97% and accuracy, as measured by inheritance in trios and concordance with the HapMap Project, is >99.7%. Average intermarker distance is 23.6 kb, and 92% of the genome is within 100 kb of a SNP marker. Average heterozygosity is 0.30, with 105,511 SNPs having minor allele frequencies >5%.Keywords
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