Immunity to infection in IL‐17‐deficient mice and humans
Open Access
- 5 September 2012
- journal article
- review article
- Published by Wiley in European Journal of Immunology
- Vol. 42 (9), 2246-2254
- https://doi.org/10.1002/eji.201242605
Abstract
Mice with defective IL‐17 immunity display a broad vulnerability to various infectious agents at diverse mucocutaneous surfaces. In humans, the study of patients with various primary immunodeficiencies, including autosomal dominant hyper‐IgE syndrome caused by dominant‐negative STAT3 mutations and autosomal recessive autoimmune polyendocrinopathy syndrome type 1 caused by null mutations in AIRE, has suggested that IL‐17A, IL‐17F and/or IL‐22 are essential for mucocutaneous immunity to Candida albicans. This hypothesis was confirmed by the identification of rare patients with chronic mucocutaneous candidiasis (CMC) due to autosomal recessive IL‐17RA deficiency and autosomal dominant IL‐17F deficiency. Heterozygosity for gain‐of‐function mutations in STAT1 in additional patients with CMC was recently shown to inhibit the development of IL‐17 T cells. Although the infectious phenotype of patients with CMC and inborn errors of IL‐17 immunity remains to be finely delineated, it appears that human IL‐17A and IL‐17F display redundancy for protective immunity in natural conditions that is not seen in their mouse orthologs in experimental conditions.Keywords
This publication has 125 references indexed in Scilit:
- IL‐23‐dependent IL‐17 drives Th1‐cell responses following Mycobacterium bovis BCG vaccinationEuropean Journal of Immunology, 2011
- Exacerbated egg‐induced immunopathology in murine Schistosoma mansoni infection is primarily mediated by IL‐17 and restrained by IFN‐γEuropean Journal of Immunology, 2011
- The role of Th17 cytokines in primary mucosal immunityCytokine & Growth Factor Reviews, 2010
- Immunodeficiency due to mutations in ORAI1 and STIM1Clinical Immunology, 2010
- Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infectionMucosal Immunology, 2010
- Th17 cells at the crossroads of innate and adaptive immunity against infectious diseases at the mucosaMucosal Immunology, 2009
- Exogenous IFN‐γ ex vivo shapes the alloreactive T‐cell repertoire by inhibition of Th17 responses and generation of functional Foxp3+ regulatory T cellsEuropean Journal of Immunology, 2008
- Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndromeNature, 2008
- TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1Nature Medicine, 2007
- Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsNature, 2006