Naive CD4+ T Lymphocytes Circulate through Lymphoid Organs To Interact with Endogenous Antigens and Upregulate Their Function
Open Access
- 1 May 2010
- journal article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 184 (9), 4646-4653
- https://doi.org/10.4049/jimmunol.0903946
Abstract
Naive T lymphocytes recirculate through the lymph-vascular system and enter and exit lymphoid organs. Using mice expressing the photoconvertible fluorescence protein Kaede, we demonstrated that naive T cells seek to interact with endogenous Ags after migrating to the lymphoid organs. The interaction with endogenous Ags transiently induces CD69 expression on T cells, which prolongs retention in the lymphoid organs. Cells that fail to express CD69 or lose CD69 expression migrate to other lymphoid organs. Functionally, CD69+-naive CD4+ T cells exhibit faster and greater cytokine production than do CD69− naive CD4+ T cells. These results indicate that CD4+ T cells continuously migrate to interact with endogenous Ags, and such an interaction plays an important role in the Ag reactivity of naive CD4+ T cells.Keywords
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