Impact of Discrepancies in General and Abdominal Obesity on Major Adverse Cardiac Events
Open Access
- 17 September 2019
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Journal of the American Heart Association
- Vol. 8 (18), e013471
- https://doi.org/10.1161/jaha.119.013471
Abstract
Background Body mass index and waist circumference ( WC ) are commonly used metrics that reflect general obesity and abdominal obesity. However, the impact of general and abdominal obesity discrepancies on the risk for major adverse cardiac events ( MACE ) is less explored. Methods and Results The study population was derived from the Korean National Health Insurance Service‐Health Screening Cohort. Among 315 982 participants aged 40 years or older who underwent health examinations between 2008 and 2009, body mass index and WC were used to determine the obesity status. The participants were followed from January 1, 2010 for MACE until December 31, 2015. Cox proportional hazards models were used to evaluate the association of obesity and the risk of MACE . Compared with men who were not obese, those with abdominal obesity without general obesity (adjusted hazard ratio ( aHR ) 1.29, 95% CI 1.16–1.43), and general and abdominal obesity ( aHR 1.20, 95% CI 1.12–1.29) had elevated risk of MACE , while those with general obesity without abdominal obesity ( aHR 1.06, 95% CI 0.98–1.16) did not. Similarly, women with abdominal obesity without general obesity ( aHR 1.13, 95% CI 1.03–1.24) and those with general and abdominal obesity ( aHR 1.15, 95% CI 1.06–1.25) had increased risk of MACE , while those with general obesity without abdominal obesity ( aHR 1.07, 95% CI 0.88–1.30) did not. Conclusions Abdominal obesity without general obesity was associated with an elevated risk of major cardiovascular outcomes while general obesity without abdominal obesity did not. Concurrent determination of body mass index and WC may be beneficial for the accurate determination of future cardiovascular risk.Keywords
This publication has 54 references indexed in Scilit:
- General and abdominal obesity parameters and their combination in relation to mortality: a systematic review and meta-regression analysisEuropean Journal of Clinical Nutrition, 2013
- Relationships between Obesity and Cardiovascular Diseases in Four Southern States and ColoradoJournal of Health Care for the Poor and Underserved, 2011
- Separate and combined associations of body-mass index and abdominal adiposity with cardiovascular disease: collaborative analysis of 58 prospective studiesThe Lancet, 2011
- Impact of Abdominal Visceral and Subcutaneous Adipose Tissue on Cardiometabolic Risk Factors: The Jackson Heart StudyJournal of Clinical Endocrinology & Metabolism, 2010
- Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studiesThe Lancet, 2009
- Contribution of Obesity and Abdominal Fat Mass to Risk of Stroke and Transient Ischemic AttacksStroke, 2008
- Metabolic syndrome—a new world‐wide definition. A Consensus Statement from the International Diabetes FederationDiabetic Medicine, 2006
- ObesityThe Lancet, 2005
- Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular diseaseAmerican Heart Journal, 2005
- Borderline hypertension and obesity: two prehypertensive states with elevated cardiac output.Circulation, 1982