Neural correlates of stimulus-response and response-outcome associations in dorsolateral versus dorsomedial striatum
Open Access
- 1 January 2010
- journal article
- Published by Frontiers Media SA in Frontiers in Integrative Neuroscience
- Vol. 4, 12
- https://doi.org/10.3389/fnint.2010.00012
Abstract
Considerable evidence suggests that there is functional heterogeneity in the control of behavior by the dorsal striatum. Dorsomedial striatum may support goal-directed behavior by representing associations between responses and outcomes (R-O associations). The dorsolateral striatum, in contrast, may support motor habits by encoding associations between stimuli and responses (S-R associations). To test whether neural correlates in striatum in fact conform to this pattern, we recorded single-units in dorsomedial and dorsolateral striatum of rats performing a task in which R-O contingencies were manipulated independently of S-R contingencies. Among response-selective neurons in both regions, activity was significantly modulated by the initial stimulus, providing evidence of S-R encoding. Similarly, response selectivity was significantly modulated by the associated outcome in both regions, providing evidence of R-O encoding. In both regions, this outcome-modulation did not seem to reflect the relative value of the expected outcome, but rather its specific identity. Finally, in both regions we found correlates of the available action-outcome contingencies reflected in the baseline activity of many neurons. These results suggest that differences in information content in these two regions may not determine the differential roles they play in controlling behavior, demonstrated in previous studies.Keywords
This publication has 67 references indexed in Scilit:
- Acquisition and Performance of Goal-Directed Instrumental Actions Depends on ERK Signaling in Distinct Regions of Dorsal Striatum in RatsJournal of Neuroscience, 2010
- Ventral Striatal Neurons Encode the Value of the Chosen Action in Rats Deciding between Differently Delayed or Sized RewardsJournal of Neuroscience, 2009
- Neuronal Correlates of Instrumental Learning in the Dorsal StriatumJournal of Neurophysiology, 2009
- Dynamic Encoding of Responses and Outcomes by Neurons in Medial Prefrontal CortexJournal of Neuroscience, 2009
- Dynamic Encoding of Action Selection by the Medial StriatumJournal of Neuroscience, 2009
- Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skillNature Neuroscience, 2009
- Calculating Consequences: Brain Systems That Encode the Causal Effects of ActionsJournal of Neuroscience, 2008
- Value Representations in the Primate Striatum during Matching BehaviorNeuron, 2008
- Dopamine neurons encode the better option in rats deciding between differently delayed or sized rewardsNature Neuroscience, 2007
- Encoding of Time-Discounted Rewards in Orbitofrontal Cortex Is Independent of Value RepresentationNeuron, 2006