Studies on the mechanism of hepatotoxicity of 4-methylphenol (p-cresol): effects of deuterium labeling and ring substitution
- 10 June 1996
- journal article
- research article
- Published by Elsevier BV in Chemico-Biological Interactions
- Vol. 101 (1), 1-11
- https://doi.org/10.1016/0009-2797(96)03707-6
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- The influence of 4-alkyl substituents on the formation and reactivity of 2-methoxy-quinone methides: evidence that extended π-conjugation dramatically stabilizes the quinone methide formed from eugenolChemico-Biological Interactions, 1995
- o-Methoxy-4-alkylphenols That Form Quinone Methides of Intermediate Reactivity Are the Most Toxic in Rat Liver SlicesChemical Research in Toxicology, 1995
- Quinone Methide Formation from Para Isomers of Methylphenol (Cresol), Ethylphenol, and Isopropylphenol: Relationship to ToxicityChemical Research in Toxicology, 1995
- Cresol Isomers: Comparison of Toxic Potency in Rat Liver SlicesToxicology and Applied Pharmacology, 1994
- Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituentsXenobiotica, 1993
- The enzymic formation and chemical reactivity of quinone methides correlate with alkylphenol-induced toxicity in rat hepatocytesChemical Research in Toxicology, 1992
- Deuterium isotope effects on toluene metabolism. Product release as a rate-limiting step in cytochrome P-450 catalysisBiochemical and Biophysical Research Communications, 1989
- Steady-state and stopped-flow kinetic measurements of the primary deuterium isotope effect in the reaction catalyzed by p-cresol methylhydroxylaseBiochemistry, 1987
- Isotope effects on the metabolism and pulmonary toxicity of butylated hydroxytoluene in mice by deuteration of the 4-methyl groupToxicology and Applied Pharmacology, 1983
- Formolysis of 4-(p-methoxyphenyl)butyl p-bromobenzenesulfonateJournal of the American Chemical Society, 1974