Recent Advances of Polycationic siRNA Vectors for Cancer Therapy
- 1 August 2020
- journal article
- review article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 21 (8), 2966-2982
- https://doi.org/10.1021/acs.biomac.0c00438
Abstract
Small interfering RNAs (siRNAs) have recently emerged as a new class of biopharmaceuticals for the treatment of various diseases, including genetic diseases, viral infections, heritable disorders, and most prominently, cancer. However, clinical applications of siRNA-based therapeutics throu intravenous administration have been limited due to their rapid degradation and renal clearance, poor cellular uptake, low cytoplasmic release by escaping endocytic uptake, and off-target effects. The success of siRNA-based therapeutics depends upon the design and creation of efficient delivery vectors that should be able to protect siRNA from in vivo degradation and specifically deliver siRNA to cytosol of target cells. Over the past decade, myriad types of carrier systems composed of cationic polymers have been designed for delivery of siRNA to tumor cells. In this review, we overview recent advances in siRNA delivery by using these promising nonviral carrier systems in diverse approaches to overcome the delivery hindrances and provide valuable understanding to direct the future design of siRNA delivery carriers.Funding Information
- Ministry of Science and Technology of the People's Republic of China (2017YFD0400203)
- Natural Science Foundation of Jiangsu Province (BK20170730)
- National Natural Science Foundation of China (21676291, 21878337, 51803238, 51973233)
- Leading Talents in Schoow Technological Innovation and Entrepreneurship (WC201816)
- Jiangsu Agriculture Science and Technology Innovation Fund (CX(18)3039)
- Jiangsu Specially-Appointed Professor Program
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