NPC1L1 and cholesterol transport
Open Access
- 19 March 2010
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (13), 2740-2747
- https://doi.org/10.1016/j.febslet.2010.03.030
Abstract
The polytopic transmembrane protein, Niemann–Pick C1‐Like 1 (NPC1L1), is enriched in the apical membrane of small intestine absorptive enterocytes where it mediates extracellular sterol transport across the brush border membrane. It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that lowers blood cholesterol in humans. NPC1L1 is also highly expressed in human liver. The hepatic function of NPC1L1 may be to limit excessive biliary cholesterol loss. NPC1L1‐dependent sterol uptake seems to be a clathrin‐mediated endocytic process and is regulated by cellular cholesterol content. Recently, NPC1L1 inhibition has been shown to have beneficial effects on components of the metabolic syndrome, such as obesity, insulin resistance, and fatty liver, in addition to atherosclerosis.Keywords
Funding Information
- Ruth L. Kirschstein National Research Service Award (NRSA) (#1F32DK084582-01)
- American Heart Association (#0635261N)
- Wake Forest University Health Sciences
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