Selectively targeting Mcl-1 for the treatment of acute myelogenous leukemia and solid tumors: Figure 1.
- 15 February 2012
- journal article
- comment
- Published by Cold Spring Harbor Laboratory in Journal of Bone and Joint Surgery
- Vol. 26 (4), 305-311
- https://doi.org/10.1101/gad.186189.111
Abstract
Bcl-2, Bcl-xL, Mcl-1, and A1 are the predominant anti-apoptotic members of the Bcl-2 family in somatic cells. Malignant B lymphocytes are critically dependent on Bcl-2 or Bcl-xL for survival. In contrast, a new study by Glaser and colleagues in the January 15, 2012, issue of Genes & Development (pp. 120–125) demonstrates that Mcl-1 is essential for development and survival of acute myelogenous leukemia cells. These results provide new impetus for the generation of selective Mcl-1 inhibitors.Keywords
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