Effect of Laparoscopic-Assisted Resection vs Open Resection on Pathological Outcomes in Rectal Cancer: The ALaCaRT Randomized Clinical Trial

Abstract

Surgical removal remains the primary treatment for rectal cancer. Results have improved substantially during the past 4 decades, largely owing to adherence to the principles of total mesorectal excision.¹ Removing all of the mesorectum containing the lymph nodes and tumor is paramount for a good outcome and minimal recurrence within the pelvis.² Involvement of the circumferential resection margin (CRM) or distal resection margin and the quality of total mesorectal excision are related to local recurrence and long-term survival.³