BLACAT1 predicts poor prognosis and serves as oncogenic lncRNA in small‐cell lung cancer
- 11 September 2018
- journal article
- research article
- Published by Wiley in Journal of Cellular Biochemistry
- Vol. 120 (2), 2540-2546
- https://doi.org/10.1002/jcb.27548
Abstract
Bladder cancer‐associated transcript 1 (BLACAT1) is a novel identified long noncoding RNA (lncRNA) in bladder cancer, and has been suggested to function as an oncogenic lncRNA in several types of human cancer. However, its involvement in the progression of small‐cell lung cancer (SCLC) remained unknown. The aim of our study was to investigate the clinical value and biological function in SCLC. In our results, BLACAT1 expression was increased in SCLC tissues and cell lines compared with paired adjacent normal tissues and bronchial epithelial cell lines, respectively. In addition, BLACAT1 high‐expression was obviously associated with advanced clinical stage, large tumor size, more lymph node metastasis, present distant metastasis, and poor prognosis. Furthermore, multivariate analysis indicated that high‐expression of BLACAT1 acted as an independent poor prognostic factor for overall survival in SCLC cases. The loss‐of‐function studies suggested that of BLACAT1 suppressed SCLC cell proliferation, migration, and invasion, and induced G0/G1 phase arrest. In conclusion, BLACAT1 is associated with the malignant status and prognosis in patients with SCLC, and functions as an oncogenic lncRNA in regulating cell proliferation and motility, suggesting BLACAT1 may act as a potential target for SCLC prevention and treatment.Keywords
This publication has 26 references indexed in Scilit:
- Long noncoding RNA BLACAT1 indicates a poor prognosis of colorectal cancer and affects cell proliferation by epigenetically silencing of p15Cell Death & Disease, 2017
- Overexpression of the long non-coding RNA, linc-UBC1, is associated with poor prognosis and facilitates cell proliferation, migration, and invasion in colorectal cancerOncoTargets and Therapy, 2017
- Research progress of long noncoding RNA in ChinaIUBMB Life, 2016
- Small cell lung cancer (SCLC): no treatment advances in recent years2016
- Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?Journal of Thoracic Oncology, 2016
- Non-invasive approaches to monitor EGFR-TKI treatment in non-small-cell lung cancerJournal of Hematology & Oncology, 2015
- Small Cell Lung Cancer: Will Recent Progress Lead to Improved Outcomes?Clinical Cancer Research, 2015
- Global cancer statistics, 2012CA: A Cancer Journal for Clinicians, 2015
- Therapeutic procedure in small cell lung cancer2013
- linc-UBC1 physically associates with polycomb repressive complex 2 (PRC2) and acts as a negative prognostic factor for lymph node metastasis and survival in bladder cancerBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013