Synthesis, Characterization, and Evaluation of Phosphated Cross-Linked Konjac Glucomannan Hydrogels for Colon-Targeted Drug Delivery
- 1 January 2007
- journal article
- Published by Taylor & Francis Ltd in Drug Delivery
- Vol. 14 (6), 397-402
- https://doi.org/10.1080/10717540701202887
Abstract
Hydrogel systems of konjac glucomannan (KGM) cross-linked with trisodium trimetaphosphate (STMP) were prepared for colon-targeting drug delivery. Swelling degrees of the hydrogels were measured in artificial gastrointestinal fluids and in sodium chloride solution with different concentrations to study their dependence on the cross-linking density and the ionic strength. The absorption of methylene blue was used to characterize the degree of the KGM cross-linking. In vitro release of model drug hydrocortisone was studied in presence and absence of beta -mannanase. KGM cross-linked with STMP was able to retard the release of the poorly water-soluble drug and could be biodegraded enzymatically. Hydrocortisone release was cross-linking density dependent and controlled by degradation of the hydrogles.Keywords
This publication has 27 references indexed in Scilit:
- A novel enzymatic technique for limiting drug mobility in a hydrogel matrixJournal of Controlled Release, 2005
- Effect of glucomannan and the dosage form on ethinylestradiol oral absorption in rabbitsContraception, 2004
- Hyaluronan-based hydrogels particles prepared by crosslinking with trisodium trimetaphosphate. Synthesis and characterizationCarbohydrate Polymers, 2004
- Polysaccharides for Colon Targeted Drug DeliveryDrug Delivery, 2004
- Effect of Degree of Acetylation on Gelation of Konjac GlucomannanBiomacromolecules, 2003
- Preparation of macroporous calcium phosphate cement tissue engineering scaffoldBiomaterials, 2002
- Phosphated crosslinked guar for colon-specific drug deliveryJournal of Controlled Release, 2000
- Phosphated crosslinked guar for colon-specific drug delivery: II. In vitro and in vivo evaluation in the ratJournal of Controlled Release, 2000
- Liquid crystalline, rheological and thermal properties of konjac glucomannanPolymer, 1998
- The absorption of human calcitonin from the transverse colon of manInternational Journal of Pharmaceutics, 1996