Phytochemical screening and cytotoxicity studies of Chrysophyllum pruniforme Pierre ex Engl. barks
Open Access
- 1 January 2013
- journal article
- research article
- Published by EManuscript Technologies in Pharmacognosy Research
- Vol. 5 (3), 195-9
- https://doi.org/10.4103/0974-8490.112427
Abstract
Background: Chrysophyllum pruniforme of family sapotaceae is a plant used in traditional medicine in Gabon. Materials and Methods: In this study, C. pruniforme barks were subjected to phytochemical screening and cytotoxicity investigations. Different concentrations of aqueous and total phenolic extract were tested on mice and on human erythrocytes. Results: Phytochemical screening of C. pruniforme barks revealed the presence of flavonoids, saponins, and tannins, reducing sugars, polyphenols and traces of anthraquinones. When tested in vitro, aqueous and the phenolic extracts showed hemolytic activities on human erythrocytes with phenolic compounds being more cytotoxic than aqueous extracts. In vivo study of toxicity, allowed to determine the LD 50 at 90 mg/kg for the doses of 50, 150 and 250 mg/kg of body weight. Conclusion: These data indicate in one hand that C. pruniforme is rich in phenolic compounds and that the aqueous and total phenolic extracts could be considered as toxic for mice and maybe potentially toxic to humans in the other hand.Keywords
This publication has 9 references indexed in Scilit:
- Plant Phenolics: Extraction, Analysis and Their Antioxidant and Anticancer PropertiesMolecules, 2010
- Phytochemical Screening and Toxicity Studies on the Leaves of Capparis sepiaria Linn. (Capparidaceae).2010
- Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teasMolecular Nutrition & Food Research, 2006
- Medicinal plants: Traditions of yesterday and drugs of tomorrowMolecular Aspects of Medicine, 2006
- The malian medicinal plant Trichilia emetica; studies on polysaccharides with complement fixing abilityJournal of Ethnopharmacology, 2002
- The biological action of saponins in animal systems: a reviewBritish Journal of Nutrition, 2002
- Characterization of antigenic epitopes in anti-ulcer pectic polysaccharides from Bupleurum falcatum L. using several carbohydrasesCarbohydrate Research, 1998
- Isoquinoline Alkaloids fromArgemone mexicanaReduce Morphine Withdrawal in Guinea Pig Isolated lleumPlanta Medica, 1997
- Haemolytic activities of plant saponins and adjuvants. Effect of Periandra mediterranea saponin on the humoral response to the FML antigen of Leishmania donovaniVaccine, 1997