Endoneurial edema in sural nerve may indicate recent onset inflammatory neuropathy
- 6 October 2015
- journal article
- research article
- Published by Wiley in Muscle & Nerve
- Vol. 53 (5), 705-710
- https://doi.org/10.1002/mus.24930
Abstract
Introduction: Sural nerve biopsy is an important means of establishing the diagnosis of inflammatory neuropathies. We investigated the diagnostic value of endoneurial edema. Methods: Diagnostic sural nerve biopsies from 42 patients with inflammatory and 28 patients with noninflammatory neuropathies were re-evaluated for the presence of endoneurial edema. Edema was assessed on hematoxylin-eosin stained paraffin and frozen sections and on azure II-methylene blue stained semithin sections. We determined the area of endoneurial edema on digitized images in relation to the entire endoneurial area of each fascicle. Results: Edema was more extensive in neuropathies with short disease duration (≤12 months) as compared to long duration (>12 months; P < 0.01). Edema in inflammatory neuropathies of ≤12 months duration covered a larger area than in noninflammatory neuropathies (P < 0.01), and the extent of edema correlated negatively with disease duration (P < 0.05). Conclusions: Endoneurial edema may be a useful additional disease marker in inflammatory neuropathies of recent onset. Muscle Nerve 53: 705–710, 2016Keywords
Funding Information
- State of Bavaria
- University of Würzburg
- European Union's Seventh Framework Programme “ncRNAPain” (602133)
- Würzburg University Medical School
- ENS
This publication has 22 references indexed in Scilit:
- Chronic inflammatory demyelinating polyradiculoneuropathyCurrent Opinion in Neurology, 2013
- Nerve biopsy in chronic inflammatory neuropathies: in situ biomarkersJournal of the Peripheral Nervous System, 2011
- European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of multifocal motor neuropathy. Report of a Joint Task Force of the European Federation of Neurological Societies and the Peripheral Nerve Society – first revisionJournal of the Peripheral Nervous System, 2010
- 147th ENMC International Workshop: Guideline on processing and evaluation of sural nerve biopsies, 15–17 December 2006, Naarden, The NetherlandsNeuromuscular Disorders, 2008
- Immune-mediated components of hereditary demyelinating neuropathies: lessons from animal models and patientsThe Lancet Neurology, 2004
- Advances in understanding and treatment of immune‐mediated disorders of the peripheral nervous systemMuscle & Nerve, 2004
- Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathyAnnals of Neurology, 2001
- Matrix metalloproteinases MMP‐9 and MMP‐7 are expressed in experimental autoimmune neuritis and the guillain‐barré syndromeAnnals of Neurology, 1998
- Sensory nerve pathology in multifocal motor neuropathyAnnals of Neurology, 1996
- Inflammatory mediators in demyelinating disorders of the CNS and PNSJournal of Neuroimmunology, 1992