Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6
- 1 February 1995
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 373 (6515), 623-626
- https://doi.org/10.1038/373623a0
Abstract
The Axl receptor tyrosine kinase was identified as a protein encoded by a transforming gene from primary human myeloid leukaemia cells by DNA-mediated transformation of NIH 3T3 cells. Axl is the founding member of a family of related receptors that includes Eyk, encoded by a chicken proto-oncogene originally described as a retroviral transforming gene, and c-Mer, encoded by a human proto-oncogene expressed in neoplastic B- and T-cell lines. The transforming activity of Axl demonstrates that the receptor can drive cellular proliferation. The function of Axl in non-transformed cells and tissues is unknown, but may involve the stimulation of cell proliferation in response to an appropriate signal, namely a ligand that activates the receptor. We report here the purification of an Axl stimulatory factor, and its identification as the product of growth-arrest-specific gene 6 (ref. 6). This is, to our knowledge, the first description of a ligand for the Axl family of receptors.Keywords
This publication has 10 references indexed in Scilit:
- The Transforming Receptor Tyrosine Kinase, Axl, Is Post-translationally Regulated by Proteolytic CleavagePublished by Elsevier BV ,1995
- The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade.Molecular and Cellular Biology, 1993
- Coagulation factors X, Xa, and protein S as potent mitogens of cultured aortic smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America, 1992
- Cloning and Expression of the cDNA for Human γ-glutamyl CarboxylaseScience, 1991
- Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensorsAnalytical Biochemistry, 1991
- axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.Molecular and Cellular Biology, 1991
- Structural analysis of recombinant protein prepared by semi-dry electroblotting after sodium dodecyl sulfate-polyacrylamide gel electrophoresisElectrophoresis, 1991
- Transforming genes in chronic myelogenous leukemia.Proceedings of the National Academy of Sciences of the United States of America, 1988
- Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation.Proceedings of the National Academy of Sciences of the United States of America, 1986
- A comprehensive set of sequence analysis programs for the VAXNucleic Acids Research, 1984