Angiotensin receptor regulates cardiac hypertrophy and transforming growth factor-beta 1 expression.
- 1 May 1994
- journal article
- abstracts
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 23 (5), 587-592
- https://doi.org/10.1161/01.hyp.23.5.587
Abstract
The role of angiotensin II via the angiotensin type 1 or type 2 receptor in the development of cardiac hypertrophy was determined in adult male Sprague-Dawley rats subjected to coarctation of the abdominal aorta. Five groups of animals were studied: coarctation, coarctation plus DuP 753, coarctation plus PD 123319, sham plus DuP 753, or sham operation. Type 1 receptor blockade was accomplished with DuP 753 given in the drinking water and type 2 blockade with PD 123319 delivered by osmotic minipumps beginning with the day of surgery until 72 hours after aortic coarctation. Mean carotid blood pressures and the carotid-femoral artery blood pressure gradients were not different among coarctation, coarctation plus DuP 753, and coarctation plus PD 123319 animals. However, ratios of heart weight to body weight were higher in coarctation (4.95 +/- 0.8) or coarctation plus PD 123319 (4.52 +/- 0.5) than in sham animals (3.6 +/- 0.4; P < .005 and .05, respectively). In coarctation plus DuP 753-treated animals heart weight-body weight ratios were not different from sham or sham plus DuP 753 animals (3.9 +/- 0.4 versus 3.6 +/- 0.4 or 3.3 +/- 0.08, respectively). Type 1 receptor mRNA levels were significantly increased in the coarctation group, with the highest levels in the coarctation plus DuP 753 and sham plus DuP 753 groups. To determine whether growth factors were involved in the hypertrophic process, we measured transforming growth factor-beta 1 mRNA levels. Northern analysis demonstrated a twofold increase in coarctation animals compared with sham or coarctation plus DuP 753-treated animals.(ABSTRACT TRUNCATED AT 250 WORDS)Keywords
This publication has 27 references indexed in Scilit:
- Ontogeny of type 1 angiotensin II receptor gene expression in the rat.JCI Insight, 1993
- Role of angiotensin subtype 2 receptor in neointima formation after vascular injury.Hypertension, 1992
- Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptorBiochemical and Biophysical Research Communications, 1992
- Isolation of a cDNA encoding the vascular type-1 angiotensin II receptorNature, 1991
- Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptorNature, 1991
- Identification and characterization of angiotensin II receptor subtypes in rabbit ventricular myocardiumBiochemical and Biophysical Research Communications, 1990
- Angiogenesis by slow coronary artery occlusion in the pig heart: Expression of different growth factors mRNAsJournal of Molecular and Cellular Cardiology, 1989
- Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals.JCI Insight, 1987
- Enalapril improves systemic and renal hemodynamics and allows regression of left ventricular mass in essential hypertensionThe American Journal of Cardiology, 1984
- Variables predictive of survival in patients with coronary disease. Selection by univariate and multivariate analyses from the clinical, electrocardiographic, exercise, arteriographic, and quantitative angiographic evaluations.Cell Metabolism, 1979