Weight Change, Weight Fluctuation, and Mortality
- 9 December 2002
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Internal Medicine
- Vol. 162 (22), 2575-2580
- https://doi.org/10.1001/archinte.162.22.2575
Abstract
Objective To examine the relation between weight change and weight fluctuation (cycling) and mortality in middle-aged men. Methods A prospective study of 5608 men aged 40 to 59 years at screening, drawn from one general practice in each of 24 British towns. Changes in weight observed during a 12- to 14-year period were related to mortality during the subsequent 8 years. Results There were 943 deaths from all causes: 458 cardiovascular disease (CVD) and 485 non-CVD deaths. Those with stable weight or weight gain had the lowest total, CVD, and non-CVD mortality. Sustained weight loss or weight fluctuation (loss-gain or gain-loss) showed a significantly higher mortality risk than stable weight even after adjustment for lifestyle variables (relative risk [95% confidence interval], 1.60 [1.32-1.95], 1.50 [1.17-1.91], and 1.63 [1.24-2.14], respectively). Adjustment or exclusion of men with preexisting disease markedly attenuated the increased risk of CVD and total mortality associated with sustained weight loss and weight gain–weight loss. In long-term nonsmokers, any weight loss since screening was associated with an increased risk of mortality, but this was markedly attenuated by adjustment for preexisting disease. Recent ex-smokers showed the most marked increase in mortality associated with sustained weight loss. Conclusions The increased mortality in middle-aged men with sustained weight loss and weight fluctuation (cycling) is determined to a major extent by disadvantageous lifestyle factors and preexisting disease. The evidence suggests that weight loss and weight fluctuation (cycling) in these men does not directly increase the risk of death.Keywords
This publication has 13 references indexed in Scilit:
- Is Weight Loss Hazardous?Nutrition Reviews, 2009
- Twenty year follow-up of a cohort based in general practices in 24 British townsPublished by Oxford University Press (OUP) ,2000
- Associations of weight change and weight variability with cardiovascular and all-cause mortality in the Chicago Western Electric Company Study.American Journal of Epidemiology, 2000
- Characteristics of Older Men Who Lose Weight Intentionally or UnintentionallyAmerican Journal of Epidemiology, 2000
- Does weight cycling present a health risk?The American Journal of Clinical Nutrition, 1996
- Association of Weight Loss and Weight Fluctuation with Mortality among Japanese American MenThe New England Journal of Medicine, 1995
- Physical activity and ischaemic heart disease in middle-aged British men.Heart, 1991
- Variability of Body Weight and Health Outcomes in the Framingham PopulationThe New England Journal of Medicine, 1991
- Improving long-term weight loss: Pushing the limits of treatmentBehavior Therapy, 1987
- British Regional Heart Study: cardiovascular risk factors in middle-aged men in 24 towns.BMJ, 1981